Angiopoietin-2 and Glomerular Proteinuria

Angiopoietin-2 and glomerular proteinuria.

Kidney Int 63: 826–834, 2003 16. Cosgrove D, Meehan DT, Grunkemeyer JA, Kornak JM, Sayers R, Hunter WJ, Samuelson GC: Collagen COL4A3 knockout: A mouse model of autosomal Alport’s syndrome. Genes Dev 10: 2981–2992, 1996 17. Jarad G, Cunningham J, Shaw AS, Miner JH: Proteinuria precedes podocyte abnormalities in Lamb2 / mice, implicating the glomerular basement membrane as an albumin barrier. J ...

Podocyte-specific expression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endothelia.

Angiopoietin-2 (Ang-2) modulates embryonic vascular differentiation primarily by inhibiting the antiapoptotic effects of Ang-1 on endothelia that express the Tie-2 receptor. Ang-2 is transiently expressed by developing glomeruli but is downregulated with normal maturation. Glomerular Ang-2 expression is, however, markedly upregulated in animal models of diabetic nephropathy and glomerulonephrit...

Acquired alpha 2 antiplasmin deficiency in glomerular proteinuria.

Angiopoietin-like 4 based therapeutics for proteinuria and kidney disease

Current drugs used to treat proteinuric disorders of the kidney have been borrowed from other branches of medicine, and are only partially effective. The discovery of a central, mechanistic role played by two different forms of the secreted glycoprotein angiopoietin-like 4 (Angptl4) in human and experimental glomerular disease has opened new treatment avenues. Localized upregulation of a hyposi...

Adriamycin alters glomerular endothelium to induce proteinuria.

The pathophysiology underlying the nephrotic syndrome is becoming clear for several inherited podocytopathies; the mechanisms of injury that lead to the acquired forms of this disease are not well understood. We explored these mechanisms using the mouse model of adriamycin-induced proteinuria.We estimated the fractional clearances for FITC-Ficolls, albumin, and neutral albumin in cooled, isolat...